Endocannabinoid system & homeostasis: we explain!

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How does CBD work on our endocannabinoid system?

Our body is constantly subjected to various internal and external stresses. Outdoor temperature, climate, emotions, hormonal rhythms, heart rate, etc. To preserve the cerebral and physical balance of the human body, we possess in our central nervous system, like other mammals, an internal system responsible for homeostasis. From the Greek hómoios "similar", and stásis, "stability, action to stand up". It is therefore the endocannabinoid system (ECS) that maintains our balance by compelling our body and mind to adapt, regulate, repair and protect themselves. Constantly.

Why the name of this system is made from the root of the word cannabis? What is the connection?

A system discovered during research on .. cannabis!

It is in the 60 years that an Israeli researcher, Raphael Méchoulam, is interested in cannabis. The professor and his colleague Yuval Shvo begin by discovering the molecular structure of cannabidiol or CBD, isolated by Adams in 1940. And this in order to study the actions of the molecule. But that does not interest many people. While with the knowledge he has today, Méchoulam says "that CBD is an anti-inflammatory that reduces the symptoms of rheumatoid arthritis. It also has an effect on 1 type diabetes. We do not yet understand how it works but we know that its toxicity is very low. "

A few years later, he identifies other substances found in cannabis, and names them "cannabinoids". He discovers Tetrahydrocannabinol, commonly known as THC. That all hash smokers know because it is the psychoactive molecule of the plant. With CBD, THC becomes the other main cannabinoid of the cannabis plant. Which also includes secondary cannabinoids and terpenes (aromatic molecules).

In the 80 years, an American team found on brain cells, "receptors" that are activated when taking THC. "If evolution had endowed our body with such receptors, it was obviously not to perceive the effects of marijuana. But because the body itself produces, in response to a specific need, molecules similar to THC "concludes Méchoulam. And he called these internal cannabinoids to the human body: the "endocannabinoids" (of "endo" which means inside).

In 1992, with his team he isolates the first endocannabinoid, made by the body to respond to the signal of pain. Mechulam will say of this neurotransmitter "It was called" Anandamide ", ananda for joy in Sanskrit, a language studied by a researcher of the team.

The system therefore works with endocannabinoid receptors, the first two of which are identified in the 90 years. This is the CB1 receiver discovered in 1990 and the CB2 receiver, in 1993. CB1 receptors are predominantly present in the central and peripheral nervous system. But also in many other organs and tissues. CB2 receptors predominate in immune tissues.

Thus discovered after discovery, Professor Méchoulam reconstitutes the puzzle of the different elements of a complex endogenous system, the endocannabinoid system.

Functions of the endocannabinoid system

Its primary function is to ensure the balance of the body. For this, it regulates a very large number of physical and psychic processes including neuronal development, cardiovascular function, inflammation, immunity, regulation of stress and emotional state, appetite, metabolism, digestion, development and bone density, learning, sensory perception, psychomotor behavior, psychological disorders, memory, sleep and wake cycles, etc.

It adapts to most pathological situations, among others, by increasing the rate of anandamide. "Animal research has shown that the amount of anandamide in the gut multiplies if the animals are starved for a period of time, and this rate normalizes again if they re-fill sufficiently. It has also been demonstrated that the production of endocannabinoids in the body is greatly increased during muscle cramps, in cases of pain caused by neuritis or chronic inflammations of the intestine. This system plays an important role in cerebral hypoxia by curbing the excessive release of glutamate in the brain. That's why, at the current stage of research, one of the main functions attributed to endocannabinoids is the protective function of nerve cells, "says Dr. Franjo Gotenhermen, a German physician, known as a scientific and medical advocate for the cannabis plant.

CBD, a main cannabinoid that supports ECS

The law prohibits THC in a so-called "recreational" configuration. But admits it under certain conditions in a therapeutic setting. This is therapeutic cannabis which is in the medical field. On the other hand, the law has relaxed with regard to the CBD. This one is neither psychoactive nor addictive and, as Professor Méchoulam says, presenting only a very low toxicity. Indeed, CBD has almost no undesirable side effects.

When the body suffers too much stress, pressure, tension, the ECS reaches, in a way, its limits. He can no longer help the body and mind to manage, regulate, adapt. The system then sends alarm signals. We are overwhelmed by stress. We eat more unbalanced. Too much sugar, alcohol and industrialized products. We sleep badly, we smoke too much, we get discouraged, we get depressed, etc.

Without listening to distress signals, a vicious circle may develop, potentially causing other symptoms. In particular inflammatory syndromes.

In reality, one needs rest, sleep, sport, meditation, holidays, etc. CBD is another option. He supports the endocannabinoid system.

The effects of CBD

It acts mainly against stress and anxiety, big "diseases" of our time. When stress is no longer managed, the "restorative" functions of the body are no longer sufficient and effective. Including those who work during sleep. CBD can potentially improve the quality of sleep and defuse insomnia.

It increases the level of anandamide, this neurotransmitter that causes the feeling of well-being. And we discovered in 1996 that he was also present in the .. chocolate! A more serene mind makes it easier to deal with what is more tense and difficult in one's professional and private life. CBD can help to stay more centered, relaxed, lucid so you do not get overwhelmed. If the symptoms are more serious, of course, it's a matter of talking to a doctor.

Finally, CBD acts on the immune system by activating the receptors called CB2 that predominate in immune tissues. We know today that it is also very effective in cases of epilepsy. The case of little Charlotte Figi has been around the world.

CBD products

There is a tendency to think that it exists only as a dried plant because it is still too often and systematically associated with smoked cannabis. However, if the CBD is indeed in the form of a dried plant, it is not recommended to smoke it. Because, on the one hand, all combustion is toxic. On the other hand, the properties of some parts of the plant go up in smoke, if we can say. Terpenes in particular. The dried plant can be taken in herbal tea for example. Smokers will prefer vaping e-liquid CBD.

But there are also CBD oils that are becoming more and more popular. Take or drops sublingually (under the tongue) or capsules. In particular, detailed information on therapeutic cannabis and the various types of CBD products can be found on the website. Sensativa.

In conclusion:

The endocannabinoid system is valuable for physical and psychic balance. It is essential to support and strengthen it. Mediation and / or sport as much as possible. Good nutrition as much as possible. And if need a boost, the CBD is a good track to explore!

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