Our organism is constantly subjected to various internal and external stresses. Outdoor temperature, climate, emotions, hormonal rhythms, heart rate, etc. To preserve the cerebral and physical balance of the human body, we have in our central nervous system, just like other mammals, an internal system responsible for homeostasis. From the Greek hómoios “similar”, and stásis, “stability, action of standing up”. It is therefore the endocannabinoid system (ECS) which maintains our balance by forcing body and mind to adapt, regulate, repair, protect. Constantly. Why is this system called from the root of the word cannabis? What is the connection?
It is in the 60 years that an Israeli researcher, Raphael Méchoulam, is interested in cannabis. The professor and his colleague Yuval Shvo begin by discovering the molecular structure of cannabidiol or CBD, isolated by Adams in 1940. And this in order to study the actions of the molecule. But that does not interest many people. While with the knowledge he has today, Méchoulam says "that CBD is an anti-inflammatory that reduces the symptoms of rheumatoid arthritis. It also has an effect on 1 type diabetes. We do not yet understand how it works but we know that its toxicity is very low. "
A few years later, he identified other substances found in cannabis, and named them "cannabinoids". He discovers Tetrahydrocannabinol, commonly known as THC. That all hashish smokers know because it is the psychoactive molecule of the plant. Along with CBD, THC becomes the other main cannabinoid in the cannabis plant. Which also includes secondary cannabinoids and terpenes (aromatic molecules). In the 80s, an American team observed “brain receptors” on brain cells that activate when they take THC.
“If evolution had endowed our organism with such receptors, it was obviously not to perceive the effects of marijuana. But because the body itself produces, in response to a specific need, molecules similar to THC ”concludes Méchoulam. And he called these cannabinoids internal to the human organism: “endocannabinoids” (from “endo” which means inside). In 1992, with his team he isolated the first endocannabinoid, made by the body to respond to the pain signal. Méchoulam will say of this neurotransmitter "We baptized him" anandamide ", ananda for joy in Sanskrit, a language studied by a researcher of the team."
The system therefore works with endocannabinoid receptors, the first two of which were identified in the 90s. These are the CB1 receptor discovered in 1990 and the CB2 receptor in 1993. CB1 receptors are mainly present in the central nervous system and peripheral. But also in many other organs and tissues. CB2 receptors predominate in immune tissues. Thus, discovery after discovery, Professor Méchoulam reconstructs the puzzle of the different elements of a complex endogenous system, the endocannabinoid system.
Its primary function is to ensure the balance of the body. For this, it regulates a very large number of physical and psychic processes including neuronal development, cardiovascular function, inflammation, immunity, regulation of stress and emotional state, appetite, metabolism, digestion, development and bone density, learning, sensory perception, psychomotor behavior, psychological disorders, memory, sleep and wake cycles, etc.
It adapts to most pathological situations, among others, by increasing the level of anandamide. "Research in animals has shown that the amount of anandamide in the gut increases if the animals are starved for a period of time, and that this rate normalizes again if they get enough food." It has also been shown that the production of endocannabinoids in the body is greatly increased during muscle cramps, in case of pain caused by neuritis or chronic inflammation of the intestine.
This system plays an important role in cerebral hypoxia by slowing the excessive release of glutamate in the brain. This is why, at the present stage of research, one of the main functions attributed to endocannabinoids is the protective function of nerve cells. " says Doctor Franjo Gotenhermen, a German doctor known as a scientific and medical defender of the cannabis plant.
It acts mainly against stress and anxiety, major “diseases” of our time. When you can no longer manage stress, the "restorative" functions of the body are no longer sufficient and effective. Including those who work during sleep. CBD can potentially improve the quality of sleep and defuse insomnia. It increases the level of anandamide, this neurotransmitter which causes the feeling of well-being. And which we discovered in 1996 that it was also present in .. chocolate! A more serene mind makes it easier to face what is more tense and difficult in his professional and private life. CBD can help you stay more focused, relaxed, lucid so you don't get overwhelmed. If the symptoms are more serious, of course, it is a matter of going to a doctor. Finally, CBD acts on the immune system by activating the receptors called CB2 which predominate in immune tissues. We now know that it is also very effective in epilepsy cases. The case of little Charlotte Figi has been around the world.
We tend to think that it only exists in the form of a dried plant because it is still too often and systematically associated with smoked cannabis. However if CBD is indeed in the form of a dried plant, it is not recommended to smoke it. Because, on the one hand, all combustion is toxic. On the other hand, the properties of certain parts of the plant go up in smoke, so to speak. Terpenes in particular. The dried plant can be taken as a tea for example. Smokers will prefer vaping CBD e-liquids. But there are also CBD oils that are becoming more and more popular. Take it or in sublingual drops (under the tongue) or in capsules. In particular, detailed information on medical cannabis and the different types of CBD products can be found on the website. Sensativa.