CBD vd. CBDa: what are the differences between these molecules?

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Cannabis, whether from the Sativa L or Indica varieties, is composed of terpenes, aromatic molecules of the plant and a hundred cannabinoids. Of which the secondary ones like CBG, CBN, etc., and the two main and popular cannabidiol (CBD) and especially tetrahydrocannabinol (THC).

THC is known for its psychotropic character that many smokers know well, focusing on its concentration rate in this cannabis called "recreational" also called weed, grass, marijuana, etc.

The CBD, devoid of any psychoactive effect gains notoriety for its own therapeutic properties: anti-stress, anti-anxiety, anti-inflammatory, etc.

But CBD is CBD only because cannabis, sativa L in this case, richer in cannabidiol, was heated to be extracted. For the record, the rate of THC to be legal must not exceed in the plant 0,2% THC.

In the raw plant, especially fresh, it is CBDa or cannabidiolic acid. The small means acid. CBDa is the precursor of CBD. Like THCa, that of THC.

What is CBDa or cannabidiolic acid?

The cannabis plant does not contain CBD as such. Cannabidoic acid (CBDA) becomes CBD only when the plant is heated and starts the decarboxylation process. The process of decarboxylation is the act of heating cannabis materials by cooking, spraying or smoking. CBDa will naturally become CBD as it is degraded, but can be converted more rapidly by decarboxylation.

At about 130 degrees Celsius, a chemical reaction removes a carboxyl group and releases carbon dioxide.

This decarboxylation process releases CBD.

CBD and CBDa, same molecule?

Although CBD is derived from CBDa, the molecules do not share the same chemical compound. In reality, they differ in several ways: their chemical composition, their individual and collective functioning, and their effects on the human body.

They have their own properties and work with each other, when in contact, in "entourage effect". In the sense that the interaction between the molecules present give more power to their effects than when they operate separately.

When CBD and CBDa are in contact with other cannabinoids and terpenes, the surrounding effect is maximal.

CBD and CBDa, complementary?

1 - Chemical compositions

The chemical formulas of CBD and CBDa are respectively C21H30O2 and C22H30O4. CBD has a simpler chemical composition due to the absence of a carboxylic acid group that is removed during the decarboxylation process. Removal of the carboxyl group converts the inactive components of CBDa into active components, thereby releasing additional therapeutic properties.

2 - The operations

CBD and CBDa both have a positive impact on the body's endocannabinoid system (ECS), which serves to regulate the balance of immune response, cellular communication, metabolism, mood, and other functions. body.

In terms of "functioning", the main differences between CBD and CBDa reside in the types of receptors they influence:

  • CBD is known to react with adenosine, serotonin and vanilloid receptors to reduce stress, anxiety, muscle tension and other disorders.
  • CBD also inhibits the CPR55 receptor to improve bone density in particular.
  • CBDa works by reducing the activity of the receptors responsible for inflammation.

3 - Complementarity CBD / CBDa

The researchers found that CBD and CBDa provide the best results when working together. CBDa can increase the power of CBD. This also allows users to take a smaller amount of CBD while maintaining its level of efficiency.

The potential benefits of CBDa?

Given the interest in CBD, studies on cannabiodiolic acid are still insufficient. Nevertheless, preliminary laboratory research indicates that CDBa could be of interest in the following areas:

1 - Antibacterial

A US study in 2000 published in the Journal of Nutraceuticals, Functional & Medical Foods found that plants with higher concentrations of CBDA had stronger antimicrobial activity.

2 - Anti-Inflammatory

CBDa could reduce inflammation. Laboratory research on cell cultures has shown that CBDa has potential anti-inflammatory properties. An 2008 experiment published in Drug Metabolism and Disposition revealed that CBDa is a selective COX-2 inhibitor.

COX-2 is an enzyme that plays a role in the development of pro-inflammatory compounds called prostaglandins. This enzyme is a target of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen.

Inflammation is a natural and important response to stress, injury and illness. However, chronic inflammation is painful and can affect your health. Arthritis is an example of a chronic inflammatory condition.

2008 research revealed that naturally occurring CBDa selectively blocks the COX-2 enzyme, reducing its ability to synthesize pro-inflammatory compounds.

3 - Anti-nausea and vomiting

CDBa could be interesting in cases of nausea and vomiting because it would be more powerful than CBD. Even though CBDa does not activate the endocannabinoid system in the same way as CBD. An 2012 study published in the British Journal of Pharmacology found that CBDa treatment had reduced the nausea behavior of rodents. By comparing the action of CBD and CBDa, researchers have found that CBDa is more effective at relieving stomach upset.

4 - Anti-anxiety

Studies need to be continued in this direction. Nevertheless, an indicator of the effects of CBDa on anxiety is given by a British company GW Pharmaceuticals that included CBD-A in a patent on the use of cannabinoids in combination with antipsychotic drugs. This may also be due to more power given by CBDa to the properties of CBD, which has shown in several studies its effects on anxiety.

5 - CBD Power Booster

Higher power does not necessarily mean that it works better, but that the desired effect is achieved at a lower dose. Also, by combining CBD and CBDa, it is about taking a dosage or a lower dose to also benefit from faster effects.
Which, in absolute terms, is cheaper too. Just as the choice of absorption mode which also allows to optimize the amount absorbed. Sublingual absorption for example having a better bioavailability.

Can we turn CBDa into CBD into DIY?

DIY for Do it yourself. That is homemade manufacture.

Depending on the heat application time, decarboxylation can transform more or less CBDa into CBD. As a result, the resulting chemical compound may still contain at least traces of CBDa. Thus, this decarboxylation can be carried out by heating the dried plant containing not more than 0,2% THC (to respect the framework imposed by law) in a liquid body for example.

In this case, do not forget that cannabinoids are not soluble in water. Use any type of fat, fat, whole animal or vegetable milk, butter, oil, etc. A good herbal tea type chai is very nice. That is to say whole milk fat, spices (cinnamon, cardamom, etc.) and sugar or better, honey.

What is the easy way to take CBDa?

The raw hemp plant contains very little CBD. The ratio is about 95% of CBDa for 5% of CBD at most. Lovers of "raw" cannabis (with a maximum of 0,2 of legal THC) get their daily dose of CBDA simply by adding it to salads for example. Or drinking, not herbal teas since in this case heating the cannabis plant turns CBDa into CBD, but making a smoothie or juice, like any vegetable.

For those who want to combine the action of CBD and CBDa, it is simply a question of combining the two forms. Heated and raw. You'll take a little vegetable milkshake with dried hemp and a CBD custard? To your recipes!

You will find CBD in the form of dried hemp and infusions of CBD site on the Sensativa. As well as other complementary information.

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This post was last modified on December 14, 2019